The aim of the present work was to formulate and evaluate microballoons for the treatment of stomach ulcer. The specified objectives were to avoid the degradation of drug (esomeprazole magnesium trihydrate-first line choice of drug for the gastric ulcer treatment) in the gastric fluid and to show the local action, to prolong the gastric residence time in the stomach so that to show the sustain release action. Different formulation of microballoons was prepared by modified emulsion – solvent diffusion method for selection of different polymer like ethyl cellulose, methyl cellulose and HPMC in methanol and dichloromethane organic solvent system and it was characterized for their particle size, production yield, In-vitro floating ability, % entrapment efficiency, floating lag time. Batch (F5) containing Methyl cellulose and HPMC Showed desirable result and surface morphology study was done for selected formulation. The final formulation of was prepared by simple blend mixing of hydrocolloid polymers HPMC K15 along with sodium bicarbonate with drug loaded microballoons and filled in to the capsule. The evaluation data were fitted to pharmacokinetic release study and found that anomalous (non-Fickian) diffusion. Stabilty study of optimized formulation showed it was stable formulation.
Loading....